Publications

Publications

1. Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Lam KSL, Wong TY, …, Wu T, Sham PC, Gu D, Willer CJ. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017 Dec; 49(12):1722-1730.

2. Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N, Yao S, Xia Z*. Cardiac Protective Effects of Remote Ischaemic Preconditioning in Children Undergoing Tetralogy of Fallot Repair Surgery: A Randomized Controlled Trial. Eur Heart J. 2017 Feb.

3. Huang Z#, Zhong L, Lee JTH, Zhang J, Wu D, Geng L, Wang Y, Wong CM*, Xu A*. The FGF21-CCL11

Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. Cell Metab. 2017 Sep; 26(3): 493-508.

4. Shu L#, Hoo RL#*, Wu X, Pan Y, Lee IP, Cheong LY, Bornstein SR, Rong X, Guo J, Xu A*. A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes. Nat Commun. 2017 Jan; 8:14147.

5. Li H#, Wu G, Fang Q, Zhang M, Hui X, Sheng B, Wu L, Bao Y, Li P, Xu A*, Jia W. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018 Jan; 9(1): 272.

6. Yang JK, Wang YY, Liu C, Shi TT, Lu J, Cao X, Yang FY, Feng JP, Chen C, Ji LN, Xu A*. Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3- Year Prospective Cohort Study. Diabetes Care. 2017 Feb; 40(2): 253-260.

7. Leong AT, Chan RW, Gao PP, Chan YS, Tsia KK, Yung WH, Wu EX*. Long-range projections coordinate
distributed brain-wide neural activity with a specific spatiotemporal profile. Proc Natl Acad Sci U S A. 2016 Dec; 113(51):E8306-E8315.

8. Chan RW, Leong ATL, Ho LC, Gao PP, Wong EC, Dong CM, Wang X, He J, Chan YS, Lim LW, Wu EX*. Low-frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity. Proc Natl Acad Sci U S A. 2017 Aug; 114(33): E6972-E6981.

9. Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RC, Xu A, Wang N, Tian XY, Huang Y. PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. Diabetes. 2017 Feb; 66(2): 519-528.

10. Cheung CYY, Tang CS, Xu A, Lee CH, Au KW, Xu L, Fong CHY, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Cherny SS, Hai J, Cheung BMY, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL*. An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels. Diabetes. 2017 Jun; 66(6): 1723-1728.

11. Hui X#, Zhang M, Gu P, Li K, Gao Y, Wu D, Wang Y*, Xu A*. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO Rep. 2017 Apr; 18(4): 645-657.

12. Wang B#, Li A, Li X, Ho PW, Wu D, Wang X, Liu Z, Wu KK, Yau SS, Xu A*, Cheng KK. Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Rep. 2018 Feb.

13. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Rep. 2017 Jan; 18(3): 624-635.

14. Ong KL, O'Connell R, JanuszewskiAS, Jenkins AJ, Xu A, Sullivan DR, Barter PJ, Scott RS, Taskinen MR, Waldman B, Colman PG, Best JD, Simes JR, Rye KA, Keech AC; FIELD study investigators. Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study. Clin Chem. 2017 Jul; 63(7): 1261-1270.

15. Chen J#, Li J#, Yiu JHC, Lam JKW, Wong CM, Dorweiler B, Xu A*, Woo CW*. TRIF-dependent Toll-like receptor signaling suppresses Scd1transcription in hepatocytes and prevents diet-induced hepatic steatosis. Sci Signal. 2017 Aug; 10(491).

16. Zhang K, Guo Y, Ge Z, Zhang Z, Da Y, Li W, Zhang Z, Xue Z, Li Y, Ren Y, Jia L, Chan KH, Yang F, Yan J, Yao Z, Xu A, Zhang R. Adiponectin Suppresses T Helper 17 Cell Differentiation and Limits Autoimmune CNS Inflammation via the SIRT1/PPARγ/RORγt Pathway. Mol Neurobiol. 2017 Sep. 54(7): 4908-4920.

17. Fei Y, Tsoi MF, Kumana CR, Cheung TT, Cheung BMY*. Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs. Int J Cardiol. 2018 Mar.

18. Cheung CY, Tang CS, Xu A, Lee CH, Au KW, Xu L, Fong CH, Kwok KH, Chow WS, Woo YC, Yuen MM, Hai JS, Jin YL, Cheung BM, Tan KC, Cherny SS, Zhu F, Zhu T, Thomas GN, Cheng KK, Jiang CQ, Lam TH, Tse HF, Sham PC, Lam KS*. Exome-chip Randomized controlled trial an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals. Diabetologia. 2017 Jan; 60(1): 107-115.

19. Jiang X#, Zhou Y, WuKK, Chen Z, Xu A*, Cheng KK*. APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes. Diabetologia. 2017 Mar; 60(3):464-474.

20. Ge M, Yao W, Yuan D, Zhou S, Chen X, Zhang Y, Li H, Xia Z*, Hei Z. Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury. Cell Death Dis. 2017 Jun; 8(6).

21. Wong KHK#, Cai Y, Ying F, Chen X, Vanhoutte PM, Tang EHC*. Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations. J Mol Cell Cardiol. 2018 Feb; 115: 1-9.

22. Wong ESW#*, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PM. L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta. Anesthesiology. 2018 Mar; 128(3): 564-576.

23. Ying F#, Cai Y, Cai Y, Wang Y, Tang EHC*. Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue. FASEB J. 2017 Sep; 31(9):4023-4036.

24. Hampe L, Xu C, Harris PWR, Chen J, Liu M, Middleditch M, Radjainia M, Wang Y*, Mitra AK. Obesity-related metabolic disorders mitigated by peptides designed to modulate adiponectin assembly. British Journal of Pharmacology. 2017 Dec; 174(23):4478-4492.

25. Nie T, Zhao S, Mao L, Yang Y, Sun W, Lin X, Liu S, Li K, Sun Y, Li P, Zhou Z, Lin S, Hui X, Xu A, Ma CW, Xu Y, Wang C, Dunbar PR, Wu D. A Natural Compound Formononetin Derived From Astragalus Membranaceus Increase Adipocyte Thermogenesis by Modulating PPARγ Activity. Br J Pharmacol. 2018 Jan.

26. Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z*. Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia. Cell Physiol Biochem. 2017; 44(1): 279-292.

27. Lee CH, Woo YC, Chow WS, Cheung CYY, Fong CHY, Yuen MMA, Xu A, Tse HF, Lam KSL*. Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus. J Am Heart Assoc. 2017 Jun; 6(6).

28. Doytcheva P, Bächler T, Tarasco E, Marzolla V, Engeli M, Pellegrini G, Stivala S, Rohrer L, Tona F, Camici GG, Vanhoutte PM, Matter CM, Lutz TA, Lüscher TF, Osto E. Inhibition of Vascular c-Jun N-Terminal Kinase 2 Improves Obesity-Induced Endothelial Dysfunction After Roux-en-Y Gastric Bypass. J Am Heart Assoc. 2017 Nov; 6(11).

29. Cheung CL#, Ho DKC, Sing CW, Tsoi MF, Cheng VKF, Lee GKY, Cheung BMY*. Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese. Sci Rep. 2017 Jan; 7:41084.

30. Hoo RL#*, Shu L, Cheng KK, Wu X, Liao B, Wu D, Zhou Z, Xu A. Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2- dependent Autophagy. Sci Rep. 2017 Jan; 7: 40657.

31. Zhang J, Li H, Zhou H, Fang L, Xu J, Yan H, Chen S, Song Q, Zhang Y, Xu A, Fang Q, Ye Y, Jia W. Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose. Sci Rep. 2017 Jul; 7(1): 6042.

32. Leung RY, Cheung BM, Nguyen US, Kung AW, Tan KC, Cheung CL. Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese. Bone. 2017 Apr; 97:293-298.

33. Chen DL, Brown R, Liess C, Poljak A, Xu A, Zhang J, Trenell M, Jenkins A, Chisholm D, Samocha-Bonet D, Macefield VG, Greenfield JR. Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men. Front Physiol. 2017 Feb; 8:101.

34. Choy KW#, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR*. Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther. 2018 Mar; 364(3): 420-432.

35. Ling WC, Mustafa MR, Vanhoutte PM, Murugan DD. Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2017 May.

36. CH Lee, AZ Shih, YC Woo, CHY Fong, MMA Yuen, WS Chow, KSL Lam*. Which creatinine- based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes? Diabetes Res Clin Pract. 2017; 126:25-29.

37. KC Shih, Lam KSL Lam, L Tong. A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 2017; 7:e251

38. Woo YC, Lee CH, Fong CH, Xu A, Tso AW, Cheung BM*, Lam KS*. Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes. Clin Endocrinol (Oxf). 2017 Jan; 86(1): 37-43.

39. Wong CM#*, Xu L, Yau MY. Alternative Mrna Splicing in the Pathogenesis of Obesity. Int J Mol Sci. 2018 Feb; 19(2).

40. Baretella O#, Chung SK, Xu A, Vanhoutte PM*. Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice. Acta Pharmacol Sin. 2017 Apr; 38(4):498-512.

41. Detremmerie C#, Vanhoutte PM, Leung S*. Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone. Acta Pharm Sin B. 2017 Jul; 7(4):401-408.

42. Baretella O#, Chung SK, Xu A, Vanhoutte PM*. Paradoxical lack of increase in endothelin-1 levels in obese mice - possible role of endothelin-B receptors. Acta Pharmacol Sin. 2017 Nov; 38(12): 1699-1700.

43. Thuesen AD, Andersen K, Lyngsø KS, Burton M, Brasch-Andersen C, Vanhoutte PM, Hansen PBL. Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice. Pflugers Arch. 2018 Feb; 470(2): 355-365.

44. Shi Y, Vanhoutte PM. Macro- and microvascular endothelial dysfunction in diabetes. J Diabetes. 2017 May; 9(5):434-449.

45. Huang Z#, Xu A*, Cheung BMY*. The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension. Curr Hypertens Rep. 2017 Apr; 19(4): 28.46. Chan JS, Li A, Ng SM, Ho RT, Xu A, Yao TJ, Wang XM, So KF, Chan CL. Adiponectin Potentially Contributes to the Antidepressive Effects of Baduanjin Qigong Exercise in Women With Chronic Fatigue Syndrome-Like Illness. Cell Transplant. 2017 Mar; 26(3): 493-501.

47. Jin J, Tang Q, Li Z, Zhao Z, Zhang Z, Lu L, Zhu T, Vanhoutte PM, Leung SW, Tu R, Shi Y. Prostaglandin E2 regulates renal function in C57/BL6 mouse with 5/6 nephrectomy. Life Sci. 2017 Apr; 174:68-76.

48. Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G. Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. Am J Transl Res. 2017 Jun; 9(6): 2723-2735.

49. Jo E, Li S, Liang Q, Zhang X, Wang H, Herbert TP, Jenkins TA, Xu A, Ye JM. Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21. PLoS One. 2017 Apr; 12(4).

50. Sing CW, Wong IC, Cheung BM, Chan JC, Chu JK, Cheung CL*. Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study. Pharmacoepidemiol Drug Saf. 2017 Mar; 26(3):248-255.

51. Zhang C, Li T, Chiu KY, Wen C, Xu A, Yan CH. FABP4 as a biomarker for knee osteoarthritis. Biomark Med. 2018 Feb; 12(2): 107-118.

52. Zhu C, Zhang W, Liu J, Mu B, Zhang F, Lai N, Zhou J, Xu A, Li Y. Marine collagen peptides reduce endothelial cell injury in diabetic rats by inhibiting apoptosis and the expression of coupling factor 6 and microparticles. Mol Med Rep. 2017 Oct; 16(4): 3947-3957.

53. Duan L, Wei L, Tian Y, Zhang Z, Hu P, Wei Q, Liu S, Zhang J, Wang Y, Li D, Yang W, Zong R, Xian P, Han C, Bao X, Zhao F, Feng J, Liu W, Cao W, Zhou G, Zhu C, Yu F, Yang W, Meng Y, Wang J, Chen X, Wang Y, Shen B, Zhao B, Wan J, Zhang F, Zhao G, Xu A, Zhang X, Liu J, Zuo X, Wang K. Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study. Stroke. 2018 Jan; 49(1): 11-18.

54. Yang K#, Deng HB#, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y*. Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment. ESC Heart Fail. 2017 Nov; 4(4): 563-575.

55. Zhu C#, Zhang W, Mu B, Zhang F, Lai N, Zhou J, Xu A, Liu J, Li Y. Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats. J Food Sci Technol. 2017 Jul; 54(8): 2260-2269.

56. Cao G, Wang Q, Huang W, Tong J, Ye D, He Y, Liu Z, Tang X, Cheng H, Wen Q, Li D, Chau HT, Wen Y, Zhong H, Meng Z, Liu H, Wu Z, Zhao L, Flavell RA, Zhou H, Xu A, Yang H, Yin Z. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Cell Discov. 2017 Jun; 3: 17020.

57. Wong HS, Yeung PKK, Lai HM, Lam KSL, Wutian W, Chung SK*. Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas. Curr Protoc Cell Biol. 2017 Dec; 77:19.

58. KHM Kwok#, KSL Lam*. Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis. Endocrinol Metab (Seoul). 2017 Jun; 32(2):145-151.

59. Man AWC, Wang Y. Age-associated Arterial Remodelling and Cardiovascular Diseases. EC cardiology. 2017; 4(4) 137-164. (Book chapter)

60. Sun WY, Wang Y. Calorie Restriction Mimetics From Functional Foods: Impact on Promoting a Healthy Life Span. Nutrition and Functional Foods for Healthy Aging. 2017; pp. 257–271. (Book chapter)

61. Guo Y, Wang Y, Bai B. CDK5. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham, 2017 (online) pp.1009-1024. (Book chapter)

62. Li DH, Cao HD, Chen J, Liu M, Wang Y, Adiponectin-Based Therapeutics for Cancer Treatment (Book chapter, accepted for Frontiers in Clinical Drug Research - Anti-Cancer Agents, 2017, Vol. 4, 1-42)

1. Pan X, Shao Y, Wu F, Wang Y, Xiong R, Zheng J, Tian H, Wang B, Wang Y, Zhang Y, Han Z, Qu A, Xu H, Lu A, Yang T, Li X, Xu A, Du J, Lin Z. FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab. 2018 Jun; 27(6):1323.

2. Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y. Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin- resistant mice. Hepatology. 2018 Oct; 68(4):1361-1375.

3. Pan Y#, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A*. Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation. J Clin Invest. 2019 Feb 1; 129(2):834-849.

4. Ji X, Zhou P, Zhong L, Xu A, Tsang ACO, Chan PKL. Smart Surgical Catheter for C-Reactive
Protein Sensing Based on an Imperceptible Organic Transistor. Adv Sci, 2018 May 2;5(6):1701053.

6. Wang B#, Li A, Li X, Ho PW, Wu D, Wang X, Liu Z, Wu KK, Yau SS, Xu A*, Cheng KK*. Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Rep. 2018 Apr; 19(4) ): e44977.

7. Lee CH, Cheung CYY, Woo YC, Lui DTW, Yuen MMA, Fong CHY, Chow WS, Xu A, Lam KSL*. Circulating Adipocyte Fatty Acid-Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes. Clin Chem. 2018 Oct; 64(10):1496.

8. Yang JK, Lu J, Yuan SS, Asan, Cao X, Qiu HY, Shi TT, Yang FY, Li Q, Liu CP, Wu Q, Wang YH, Huang HX, Kayoumu A, Feng JP, Xie RR, Zhu XR, Liu C, Yang GR, Zhang MR, Xie CL, Chen C, Zhang B, Liu G, Zhang XQ, Xu A. From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell Rep. 2018 Dec; 25(13):3800.

9. Cheung CYY#, Lee CH, Tang CS, Xu A, Au KW, Fong CHY, Ng KKK, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Hai J, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL*. Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects with Type 2 Diabetes. Diabetes. 2019 Jan; 68(1):198.

10. Liu Z#, Jin L, Yang JK, Wang B, Wu KKL, Hallenborg P, Xu A*, Cheng KKY*. The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. Diabetes. 2018 Nov; 67(11):2397.

11. Nie T, Zhao S, Mao L, Yang Y, Sun W, Lin X, Liu S, Li K, Sun Y, Li P, Zhou Z, Lin S, Hui X, Xu A, Ma CW, Xu Y, Wang C, Dunbar PR, Wu D. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity. Br J Pharmacol. 2018 May; 175(9):1439.

12. Wong YK, Cheung CYY, Tang CS, Au KW, Hai JSH, Lee CH, Lau KK, Cheung BMY, Sham PC, Xu A, Lam KSL, Tse HF. Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2018 Oct; 38(10):2519.

13. Wong ESW#, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PM*. L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta. Anesthesiology. 2018 Mar; 128(3):564.

14. Duan L, Wei L, Tian Y, Zhang Z, Hu P, Wei Q, Liu S, Zhang J, Wang Y, Li D, Yang W, Zong R, Xian P, Han C, Bao X, Zhao F, Feng J, Liu W, Cao W, Zhou G, Zhu C, Yu F, Yang W, Meng Y, Wang J, Chen X, Wang Y, Shen B, Zhao B, Wan J, Zhang F, Zhao G, Xu A, Zhang X, Liu J, Zuo X, Wang K. Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study. Stroke. 2018 Jan; 49(1):11.

15. Lee CH, Cheung CYY, Woo YC, Lui DTW, Yuen MMA, Fong CHY, Chow WS, Xu A, Lam KSL*. Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes. Diabetologia. 2019 Jan; 62(1):169.

16. Ong KL, Hui N, Januszewski AS, Kaakoush NO, Xu A, Fayyad R, DeMicco DA, Jenkins AJ, Keech AC, Waters DD, Barter PJ, Rye KA. High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study). Metabolism. 2018 Nov 16. Epub. doi: 10.1016/j.metabol.2018.11.006.

17. Wood J, Tse MCL, Yang X, Brobst D, Liu Z, Pang BPS, Chan WS, Zaw AM, Chow BKC, Ye K, Lee CW, Chan CB*. BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism. 2018 Oct; 87:113.

18. Guo Y#, Xu C, Man AWC, Bai B, Luo C, Huang Y, Xu A, Vanhoutte PM, Wang Y*. Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells. Cardiovasc Res. 2019 Mar; 115(3):678.

19. Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY, Huang Y. Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovasc Res. 2019 Feb. Epub. doi: 10.1093/cvr/cvz046

20. Wong KHK#, Cai Y, Ying F, Chen X, Vanhoutte PM, Tang EHC*. Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations. J Mol Cell Cardiol. 2018 Feb; 115: 1.

21. Kosuru R, Cai Y, Kandula V, Yan D, Wang C, Zheng H, Li Y, Irwin MG, Singh S, Xia Z*. AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis. Cell Physiol Biochem. 2018; 46(4):1381.

22. Wang C, Li H, Wang S, Mao X, Yan D, Wong SS, Xia Z, Irwin MG. Repeated Non-Invasive Limb Ischemic Preconditioning Confers Cardioprotection Through PKC-Ԑ/STAT3 Signaling in Diabetic Rats. Cell Physiol Biochem. 2018; 45(5):2107.

23. Wong ESW#*, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PM. L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta. Anesthesiology. 2018 Mar; 128(3): 564.

24. Gao C, Du Q, Li W, Deng R, Wang Q, Xu A, Shen J. Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Mol Neurobiol. 2018 Dec; 55(12):9334.

25. Ying F#, Cai Y, Wong HK, Chen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A, Tang EHC*. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep; 1863(9):1029.

26. Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y, Tian XY. Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacol Res. 2019 Jan; 139:384.

27. Xiang Q, Wang C, Zhang Y, Xue X, Song M, Zhang C, Li C, Wu C, Li K, Hui X, Zhou Y, Smaill JB, Patterson AV, Wu D, Ding K, Xu Y. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem. 2018 Mar 10; 147:238.

28. Wang Y, Mak JCW, Lee MYK, Xu A, Ip MSM. Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation. Oxid Med Cell Longev . 2018 Mar; 2018:4501757.

29. Fei Y, Tsoi MF, Kumana CR, Cheung TT, Cheung BMY*. Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs. Int J Cardiol. 2018 Mar. 254: 291.

30. Huang J, Xiao Y, Zheng P, Zhou W, Wang Y, Huang G, Xu A, Zhou Z. Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes Metab Res Rev. 2019 Jan; 35(1):e3064.

31. Yau SY, Lee TH, Li A, Xu A, So KF. Adiponectin Mediates Running-Restored Hippocampal Neurogenesis in Streptozotocin-Induced Type 1 Diabetes in Mice. Front Neurosci. 2018 Oct; 12:679.

32. Choy KW#, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR*. Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther. 2018 Mar; 364(3): 420.

33. Choy KW#, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR*. Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther. 2018 Mar; 364(3):420.

34. Wang B#, Cheng KK. Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy

Balance. Int J Mol Sci. 2018 Nov; 19(11): E3552.

35. Tong KL, Mahmood Zuhdi AS, Wan Ahmad WA, Vanhoutte PM, de Magalhaes JP, Mustafa MR, Wong PF. Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome. Int J Mol Sci. 2018 May; 19(5). pii: E1467

36. Wong CM#*, Xu L, Yau MY. Alternative Mrna Splicing in the Pathogenesis of Obesity. Int J Mol Sci. 2018 Feb; 19(2). pii: E632.

37. Ling WC, Mustafa MR, Vanhoutte PM, Murugan DD. Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2018 Mar; 102:11.

38. Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X*, Nie T. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sci. 2019 Jan; 222: 117.

39. Assersen KB, Jensen PS, Briones AM, Rasmussen LM, Marcussen N, Toft A, Vanhoutte PM, Jensen BL, Hansen PBL. Periarterial fat from two human vascular beds is not a source of aldosterone to promote vasoconstriction. Am J Physiol Renal Physiol. 2018 Dec; 315(6): F1670.

40. Xiao Y, Xiao X, Xu A, Chen X, Tang W, Zhou Z. Circulating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes. J Diabetes Complications. 2018 Dec; 32(12): 1100.

41. Elie AGIM, Bloksgaard M, Sun WY, Yang K, Man AWC, Xu A, Irmukhamedov A, Riber LP, Wang Y, De Mey JGR. Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients. PLoS One. 2018 Nov 5; 13(11):e0206802.

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