2021

Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A. Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production. Sci Adv. 2021 Dec;7(50): p. eabl4024. doi: 10.1126/sciadv.abl4024. PMID: 34878840

2021

Glogowska E, Arhatte M, Chatelain FC, Lesage F, Xu A, Grashoff C, Discher DE, Patel A, Honoré E. Piezo1 and Piezo2 foster mechanical gating of K2P channels. Cell Rep. 2021 Nov 30;37(9):110070. doi: 10.1016/j.celrep.2021.110070. PMID: 34852225

2021

Hallenborg P, Jensen BAH, Fjære E, Petersen RK, Belmaâti MS, Rasmussen SS, Gunnarsson JP, Lauritzen P, Cheng KKY, Hermansson M, Sonne SB, Ejsing CS, Xu A, Kratchmarova I, Krüger M, Madsen L, Kristiansen K, Blagoev B. Adipose MDM2 regulates systemic insulin sensitivity. Sci Rep. 2021 Nov 8;11(1):21839. doi: 10.1038/s41598-021-01240-3. PMID: 34750429

2021

Wu KKL, Long KK, Lin H, Siu PMF, Hoo RLC, Ye D, Xu A, Cheng KKY. The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages. Nat. Commun. 2021 Nov 17;12(1):6637. doi: 10.1038/s41467-021-26987-1. PMID: 34789781

2021

Lee CH, Seto WK, Lui DTW, Fong CHY, Wan HY, Cheung CYY, Chow WS, Woo YC, Yuen MF, Xu A, and Lam KS. Circulating thrombospondin-2 as a novel fibrosis biomarker of nonalcoholic fatty liver disease in type 2 diabetes. Diabetes care. 2021 Sep;44(9): p. 2089-2097. doi: 10.2337/dc21-0131. PMID: 34183428.

2021

Long K, Yang Y, Lv W, Jiang K, Li Y, Lo ACY, Lam WC, Zhan C, and Wang W. Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma. Adv Sci (Weinh). 2021 Aug;8(20): p. 2101754. doi: 10.1002/advs.202101754. PMID: 34448360

2021

Zhang J, Ni Y, Qian L, Fang Q, Zheng T, Zhang M, Gao Q, Zhang Y, Ni J, Hou X, Bao Y, Xu A, Li H, Panagiotou G and Jia W. Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes. Adv Sci (Weinh). 2021 Aug;8(16): p. 2100536. doi: 10.1002/advs.202100536. PMID: 8373164

2021

Wu X, Shu L, Zhang Z, Li J, Zong J, Cheong LY, Ye D, Lam KS, Song E, Wang C, Xu A, and Hoo RLC. Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells. Adv Sci (Weinh). 2021 Jun; 8(11): p. 2003721. doi: 10.1002/advs.202003721. PMID: 34105268.

2021

Xiao Y, Shu L, Wu X, Liu Y, Cheong LY, Liao B, Xiao X, Hoo RL, Zhou Z, and Xu A. Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages. JCI Insight. 2021 Apr;6(7). doi: 10.1172/jci.insight.141814. PMID: 33690220

2020

Wang B, Lin H, Li X, Lu W, Kim JB, Xu A, Cheng KKY. The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28307-28315. doi: 10.1073/pnas.2016997117. Epub 2020 Oct 29.

2020

Liao B, Geng L, Zhang F, Shu L, Wei L, Yeung PKK, Lam KSL, Chung SK, Chang J, Vanhoutte PM, Xu A, Wang K, Hoo RLC. Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier. Eur Heart J. 2020 Sep 1;41(33):3169-3180. doi: 10.1093/eurheartj/ehaa207.

2020

Geng L, Lam KSL, Xu A. The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. Nat Rev Endocrinol. 2020 Nov;16(11):654-667. doi: 10.1038/s41574-020-0386-0. Epub 2020 Aug 6.

2020

Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention. Cell Metab. 2020 Jan 7;31(1):77-91.e5. doi: 10.1016/j.cmet.2019.11.001. Epub 2019 Nov 27.

2020

Shu L, Zhong L, Xiao Y, Wu X, Liu Y, Jiang X, Tang T, Hoo R, Zhou Z, Xu A. Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice. Clin Sci (Lond). 2020 Jul 17;134(13):1679-1696. doi: 10.1042/CS20200021. PMID: 32633320.

2020

Ong KL, Wu L, Januszewski AS, O'Connell RL, Xu A, Rye KA, Ma RCW, Li H, Jenkins AJ, Jia W, Keech AC; FIELD study investigators. Relationships of adipocyte-fatty acid binding protein and lipocalin 2 with risk factors and chronic complications in type 2 diabetes and effects of fenofibrate: A fenofibrate Intervention and event lowering in diabetes sub-study. Diabetes Res Clin Pract. 2020 Nov;169:108450. doi: 10.1016/j.diabres.2020.108450. Epub 2020 Sep 17.

2020

Yiu JHC, Can KS, Cheung J, Li J, Liu Y, Wang Y, Fung WLF, Cai J, Cheung SWM, Dorweiler B, Wan EYF, Tso P, Xu A, Woo CW. Gut microbiota-associated activation of TLR5 induces apolipoprotein A1 production in the liver. Circulation Research. 127(10):1236-1252, 2020.

2020

Wang P, Liang Y, Chen K, Yau SY, Sun X, Cheng KK, Xu A, So KF, Li A. Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice. Front Cell Neurosci. 2020 Jul 3;14:189. doi: 10.3389/fncel.2020.00189.

2020

Zhang Z, Yan B, Gao F, Li Q, Meng X, Chen P, Zhou L, Deng W, Li C, Xu W, Han S, Feng H, Li Y, Chen J, Yin Z, Liao C, Tse HF, Xu A, Lian Q. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. Mol Ther. 2020 Dec 2;28(12):2642-2661. doi: 10.1016/j.ymthe.2020.07.024. Epub 2020 Jul 25. PMID: 32755565; PMCID: PMC7704739.

2020

Ng KKK, Cheung CYY, Lee CH, Fong CHY, Kwok KHM, Li KKW, Gangwani RA, Wong IYH, Woo YC, Chow WS, Yuen MMA, Wong RLC, Xu A, Wong DSH, Sham PC, Lam KSL. Possible Modifying Effect of Hemoglobin A1c on Genetic Susceptibility to Severe Diabetic Retinopathy in Patients With Type 2 Diabetes. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):7. doi: 10.1167/iovs.61.10.7. PMID: 32756921; PMCID: PMC7441357.

2020

Gao C, Yan T, Chen X, Cheng KKY, Xu A, Shen J. APPL2 Negatively Regulates Olfactory Functions by Switching Fate Commitments of Neural Stem Cells in Adult Olfactory Bulb via Interaction with Notch1 Signaling. Neurosci Bull. 2020 Sep;36(9):997-1008. doi: 10.1007/s12264-020-00514-6. Epub 2020 May 28. PMID: 32468397; PMCID: PMC7475139.

2020

Yan D, Cai Y, Luo J, Liu J, Li X, Ying F, Xie X, Xu A, Ma X, Xia Z. FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetes. J Cell Mol Med. 2020 Jul;24(14):7850-7861. doi: 10.1111/jcmm.15418. Epub 2020 May 25. PMID: 32450616; PMCID: PMC7348139.

2020

Heshiki Y, Vazquez-Uribe R, Li J, Ni Y, Quainoo S, Imamovic L, Li J, Sørensen M, Chow BKC, Weiss GJ, Xu A, Sommer MOA, Panagiotou G. Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome. 2020 Mar 5;8(1):28. doi: 10.1186/s40168-020-00811-2. PMID: 32138779; PMCID: PMC7059390.

2020

Lee CH, Lui DTW, Cheung CYY, Fong CHY, Yuen MMA, Chow WS, Woo YC, Xu A, Lam KSL. Higher Circulating Adiponectin Concentrations Predict Incident Cancer in Type 2 Diabetes - The Adiponectin Paradox. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgaa075. doi: 10.1210/clinem/dgaa075. PMID: 32072163.

2020

Liu Z, Wu KKL, Jiang X, Xu A, Cheng KKY. The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders. Clin Sci (Lond). 2020 Jan 31;134(2):315-330. doi: 10.1042/CS20190966. PMID: 31998947.

2020

Li D, Yan Sun W, Fu B, Xu A, Wang Y. Lipocalin-2-The myth of its expression and function. Basic Clin Pharmacol Toxicol. 2020 Aug;127(2):142-151. doi: 10.1111/bcpt.13332. Epub 2019 Oct 28. PMID: 31597008.

2020

Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY, Huang Y. Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovasc Res. 2020 Jan 1;116(1):226-236. doi: 10.1093/cvr/cvz046. PMID: 30785200.

2019

Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A. Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Rep. 2019 Mar 5;26(10):2738-2752.e4. doi: 10.1016/j.celrep.2019.02.014.

2019

Douguet D, Patel A, Xu A, Vanhoutte PM, Honoré E. Piezo Ion Channels in Cardiovascular Mechanobiology. Trends Pharmacol Sci. 2019 Dec;40(12):956-970. doi: 10.1016/j.tips.2019.10.002.

2019

Leong ATL, Gu Y, Chan YS, Zheng H, Dong CM, Chan RW, Wang X, Liu Y, Tan LH, Wu EX*. Optogenetic fMRI interrogation of brain-wide central vestibular pathways. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10122-10129. doi: 10.1073/pnas.1812453116. Epub 2019 Apr 26.

2018

Pan X, Shao Y, Wu F, Wang Y, Xiong R, Zheng J, Tian H, Wang B, Wang Y, Zhang Y, Han Z, Qu A, Xu H, Lu A, Yang T, Li X, Xu A, Du J, Lin Z. FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab. 2018 Jun 5; 27(6):1323-1337.e5.

2018

Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y. Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology. 2018 Oct; 68(4):1361-1375.

2018

Pan Y#, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A*. Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation. J Clin Invest. 2019 Feb 1; 129(2):834-849.

2018

Li H#, Wu G, Fang Q, Zhang M, Hui X, Sheng B, Wu L, Bao Y, Li P, Xu A*, Jia W. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018 Jan 18; 9(1):272.

2017

Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao YT, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G; GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017 Dec; 49(12):1722-1730.

2017

Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N, Yao S, Xia Z*. Cardiac Protective Effects of Remote Ischaemic Preconditioning in Children Undergoing Tetralogy of Fallot Repair Surgery: A Randomized Controlled Trial. Eur Heart J. 2017 Feb.

2017

Huang Z#, Zhong L, Lee JTH, Zhang J, Wu D, Geng L, Wang Y, Wong CM*, Xu A*. The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. Cell Metab. 2017 Sep; 26(3): 493-508.

2017

Shu L#, Hoo RL#*, Wu X, Pan Y, Lee IP, Cheong LY, Bornstein SR, Rong X, Guo J, Xu A*. A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes. Nat Commun. 2017 Jan; 8:14147.

2017

Li H#, Wu G, Fang Q, Zhang M, Hui X, Sheng B, Wu L, Bao Y, Li P, Xu A*, Jia W. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018 Jan; 9(1): 272.

2017

Yang JK, Wang YY, Liu C, Shi TT, Lu J, Cao X, Yang FY, Feng JP, Chen C, Ji LN, Xu A. Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study. Diabetes Care. 2017 Feb; 40(2): 253-260.

2017

Hoo RL, Shu L, Cheng KK, Wu X, Liao B, Wu D, Zhou Z, Xu A. (2017). Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy. Sci Rep. 2017 Jan 17. 7:40657.

2017

Chen J, Li J1, Yiu JHC, Lam JKW, Wong CM, Dorweiler B, Xu A, Woo CW. (2017). TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. Sci. Signal. 2017 Aug 8;10(491). pii: eaal3336. doi: 10.1126/scisignal.aal3336.

2016

Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK. (2016). APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes. Diabetologia. 2016 Dec 23. doi: 10.1007/s00125-016-4185-z. [Epub ahead of print]​

2016

Li X, Cheng KK, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RL, Lam KS, Ikeda Y, Gao X, Xu A. (2016). The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells. Nat Commun. 2016 Jun 6;7:11740. doi: 10.1038/ncomms11740.​

2016

Li J, Lin S, Vanhoutte PM, Woo CW, Xu A. (2016). Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice. Circulation. 2016 Apr 25. pii: CIRCULATIONAHA.115.019645.

2016

Ye D, Yang K, Zang S, Lin Z, Chau HT, Wang Y, Zhang J, Shi J, Xu A, Lin S, Wang Y. Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2. J Hepatol. 2016 Nov;65(5):988-997. doi: 10.1016/j.jhep.2016.05.041. Epub 2016 Jun 4. Erratum in: J Hepatol. 2017 Mar;66(3):669.

2015

Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, Feng T, Zhong C, Wang Y, Lam KS, Xu A. (2015). Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 22(2):279-90.​

2015

Xu C, Cai Y, Fan P, Bai B, Chen J, Deng HB, Che CM, Xu A, Vanhoutte PM, Wang Y. (2015). Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues. Diabetes. 64(5), 1576-1590.​

2015

Lee CH, Hui EY, Woo YC, Yeung CY, Chow WS, Yuen MM, Fong CH, Xu A, Lam KS. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. J Clin Endocrinol Metab. 2015 Apr;100(4):1368-75.​

2015

Xu A, Sweeney G. Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin. Autophagy. 2015 Apr 3;11(4):723-724.​

2015

Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X, Xu A. Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. Circulation. 2015 Mar 20. pii: CIRCULATIONAHA.115.015308. [Epub ahead of print]