香港大學生物醫藥技術國家重點實驗室
State Key Laboratory of Pharmaceutical Biotechnology
The University of Hong Kong
Animal Phenotyping
Comprehensive Lab Animal Monitoring System CLAMS (Columbus Instrument)
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Oxygen consumption and carbon dioxide production.
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Respiratory exchange ratio: Selective substrate oxidation (carbohydrates/lipids).
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Home Cage Activity: Monitoring and interpreting 3D (X,Y and Z dimension) activity.
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Food & drink consumption: 24-hours monitoring.
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Core body temperature: Telemetry monitoring.
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Temperature control ( 4°C-37°C).
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Ten mice are monitored simultaneously.
All enquiries are welcome to Blade Yang (ryyang@connect.hku.hk)
The Minispec LF90 Body Composition Analyzer (Bruker)
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Non-invasive measurement of lean tissue, fat, and fluid in live rodent models.
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Rapid analysis: less than 2 minutes and no sample preparation.
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Stress-free measurements.
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For both mice and rats (up to 800 gram).
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Allows frequent testing because of negligible risk to animal health.
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Longitudinal studies become possible.
All enquiries are welcome to Dr. Gandhervin Kesavamoorthy (gandherv@hku.hk)
Wire Myography for Isometric Tension Recording (Danish Myo Technology DMT)
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Measurement of isometric tension in isolated arterial rings ex vivo under physiological conditions (37 °C, pH 7.4) as an approximation for vascular function in vivo.
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High sensitivity for determinations e.g. in mouse aorta, carotid, mesenteric and renal arteries.
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Evaluation of endothelial dysfunction in murine disease models and transgenic animals.
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Four rings can be examined in parallel per system.
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More than twelve hours viability of the preparations allowing sequential concentration-response curves to pharmacological and physiological substances.
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Digital recording for data analysis on personal computer using LabChart® software.
All enquiries are welcome to Blade Yang (ryyang@connect.hku.hk)
BP-2000 Blood Pressure Analysis System (Visitech Systems)
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Non-invasive determination of blood pressure and pulse rate in unanesthetized mice.
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Tail-cuff system having high correlation with invasive measurements in unrestrained animals.
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Approximately 30 minutes recording per set.
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Four mice can be examined in parallel (platform for rats also available).
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Screening of transgenic animals for changes in blood pressure, continuous monitoring.
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Digitally recorded raw data exportable to Excel®.
All enquiries are welcome to Blade Yang (ryyang@connect.hku.hk)
Animal Treadmill (Columbus Instrument) for exercise study
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3 individual lanes for rats; 6 individual lanes for mice.
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Single belt construction.
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Unique wide range of speed adjustable from 3 to 100 meters per minute.
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Adjustable acceleration in 0.1 meter/minute-steps per second.
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Digital display of distance traveled, time and counts touch on electrical stimulus.
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Adjustable inclination: 0-25°.
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Electrical stimulus with individual on/off switches per lane.
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Belt texture facilitates animal grip.
All enquiries are welcome to Dr. Gandhervin Kesavamoorthy (gandherv@hku.hk)
Small Animal Intensive Care Unit (Harvard Apparatus)
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Provide thermoneutral environment (30 °C) for mice to avoid thermostress and thus determine the thermogenic capacity at a basal level.
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Speed recovery for mice after surgery.
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Fluid heating method could eliminate hot spots and ensure sustainable temperatures.
All enquiries are welcome to Qin Wang (wangqin1@connect.hku.hk)
Hyperinsulinemic-euglycemic Clamp
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Gold standard for assessing insulin action in vivo.
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Hyperinsulinemia is achieved by a constant insulin infusion.
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Euglycemia is maintained via a concomitant glucose infusion at a variable rate.
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Isotopic 2[14C] deoxyglucose allows to assess tissue-specific glucose uptake
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[3-3H] glucose allows to assess glucose production and disposal.
All enquiries are welcome to Baile Wang (blwong@hku.hk)
Implantable Telemetry System(Data Sciences International)
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Blood pressure measured via carotid artery.
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Biopotential signals such as ECG, EMG, EEG or EOG.
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Core body temperature.
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Locomotor activity.
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Direct measurements free from the effects of anesthesia and stress.
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Long term monitoring with or without pharmacological treatments.
All enquiries are welcome to Jingyang Song (songjy92@163.com) at 39179257
Vevo® 2100 System
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Superior resolution and image uniformity through entire field of view.
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30 micron resolution.
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Frame rates in 2D up to 740 fps (for a 4x4 mm field of view).
All enquiries are welcome to Leigang Jin (jinlg520@connect.hku.hk)