Transgenic & Knockout Mice

Transgenic & Knockout Mice

Strain

Name

Genotype

Description

B6.Cg-Tg(Fabp4-cre)1Rev/J

Adipocyte and macrophage cre

Fabp4-Cre

Transgenic mice expressing Cre recombinase driven by mouse Fabp4 promoter. These FABP4-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in brown, white adipose tissue and macrophages.
Application
For generation of adipocyte- or macrophage- specific knockout mice (...Further Info)

B6;FVB-Tg(Adipoq-cre)1Evdr/J

Adiponectin-Cre

Adipoq-Cre

Transgenic mice expressing Cre recombinase driven by the mouse adiponectin (Adipoq) promoter/enhancer regions. Adipoq-Cre BAC transgenic mice are a Cre-lox tool for deletion of floxed sequences in white adipose tissue and brown adipose tissue, but not in activated or resident macrophages.
Application
For generation of adipocyte specific knockout mouse model

(...Further Info)

B6.Cg-Apoetm1Unc (D12Mit182-D12Mit2)/Pgn

ApoE-KO

ApoE-/-

Mouse with targeted knockout of apolipoprotein gene.
Application
Disease model for atherosclerosis and hypercholesterolemia

(...Further Info)

B6.Cg-Dock7m Leprdb/+ +/J

db/db mice

Mice with spontanonous mutation at leptin receptor gene.
Application
Disease model for obesity and type 2 diabetes (...Further Info)

FVB-Tg(Tek-cre)2352Rwng/J

Endothelium Cre

Tie2-Cre

Transgenic mice expressing the Cre recombinase driven by mouse Tek, endothelial-specific receptor tyrosine kinase (also known asTie2), promoter.
Application
Generation of endothelium specific knockout mice (...Further Info)

B6.Cg-Tg(Alb-cre)21Mgn/J

Liver Cre

Alb-Cre

Application
For generation of hepatocyte specific knockout mice (...Further Info)

B6.129P2-Lyz2tm1(cre)Ifo/J

Macrophage Cre

Lys-Cre

Mice have a Cre recombinase inserted into the lysozyme 2 gene.
Application
For generation of the myeloid cell lineage specific knockout mice (...Further Info)

STOCK Mir34atm1.2Aven/J

Microrna-34 mice

micro34-/-

Application

miR-34afl/fl mice possess loxP sites flanking the entire microRNA 34a (miR-34a) sequence (...Further Info)

B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J

Muscle Cre mice

Ckmm-cre

Transgenic mice expressing Cre recombinase driven by the muscle creatine kinase (MCK or Ckm) promoter.
Application
For generation of muscle specific knockout mice (...Further Info)

NOD/ShiLtJ

NOD mice

NOD

Disease model for type 1 diabetes. Diabetes in NOD/ShiLtJ mice is characterized by insulitis, a leukocytic infiltration of the pancreatic islets (...Further Info)

B6.129P2-Trp53tm1Brn/J (p53-fl)

p53-fl

p53fl/fl

When these p53flox mice are bred to mice with a Cre recombinase gene under the control of a promoter of interest, Trp53 expression is deleted in the tissue of interest. Exons 2-10 are flanked by loxP sites in this conditional targeted mutation. Mice homozygous for the floxed allele do not show any increase in disease incidence for at least a year. When bred to mice with a cre recombinase gene under the control of a promoter of interest, expression is deleted in the tissue of interest (...Further Info)

B6.Cg-Tg(Ins2-cre)25Mgn/J

beta-cell Cre

Ins-Cre

Transgenic mice express Cre recombinanse driven by rat insulin II promoter.
Application
For generation of pancreatic beta cell specific knockout mice

(...Further Info)

B6;129S4-Pparatm1Gonz/J

PPARα-KO mice

PPARα-/-

Mice with targeted mutation at PPARα gene.
Application
Mouse model for studying lipid metabolism, cell proliferation, diabetes, obesity, and wound healing (...Further Info)

B6;129-Sirt1tm1Ygu/J

Sirt1-fl mice

Sirt1fl/fl

Mice with A loxP-flanked neomycin cassette just upstream of exon 4 and a third loxP site downstream of exon 4 were inserted to create this targeted mutant Sirt1 allele.
Application
Disease models for studying mammary gland development, mammary cancer, apoptosis, and metabolic diseases (...Further Info)

B6;129S4-Tet1tm1.1Jae/J

TET-1 mice

TET-Tg

Mice with targeted mutation at Tet1 gene.
Application
For studies of embryonic cell pluripotency and development

(...Further Info)

STOCK Tg(TIE2GFP)287Sato/J

Tie2-GFP

Tie2GFP

Mice expressing Green Fluorescent Protein (GFP) driven by endothelial-specific receptor tyrosine kinase (Tek, formerly, Tie2) promote.
Application
For study of vascular development (...Further Info)

C3H/HeJ

TLR4-KO

TLR4-/-

A spontaneous mutation occurred in C3H/HeJ at the lipopolysaccharide response locus.
Application
Mouse model for immunology, inflammation and autoimmunity Research (...Further Info)

C57BL/6J-Ticam1Lps2/J

TIRF mice

Ticam1Lps2

/Ticam1Lps2

Chemically induced mutation at lipopolysaccharide 2 gene.
Application
Studies of immunodeficiency and host response to bacterial endotoxins and viruses (...Further Info)

All enquiries are welcome to Geng Leiluo (u3003135@connect.hku.hk).