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Dr. Wu Jiaming, Gamin
吳佳銘

Post-doctoral Fellow

PhD

HKU link

Field of Research

Clinical translational research of novel metabolic hormones and development of AI-related macromolecular biological drugs against immuno-metabolic diseases.

Biography

Dr. Jiaming Wu is a Postdoctoral Fellow at The University of Hong Kong (HKU), where he earned his PhD. He also holds a Master of Medicine from Guangdong Pharmaceutical University and a Bachelor of Chinese Medicine from Guangzhou University of Chinese Medicine. His multidisciplinary work focuses on unraveling roles of novel metabolic hormones in metabolic diseases, identifying novel druggable targets using advanced animal and primary cell models, and leveraging AI-powered multi-omics and drug discovery technologies to discover synergistic therapeutic combinations for obesity-related cardiovascular diseases, cancers, and cancer-associated cachexia.

Selected Publications

  1. Yao Wang*, Jiaming Wu*, Jianyu Yao, Jiarui Chen, Kenneth K Y Cheng, Melody Yuen-man Ho, Chi Ho Lee, Karen Siu-Ling Lam, Aimin Xu. Soluble IL-6 receptor produced by gut microbiome-adipose tissue crosstalk regulates exercise responsiveness for diabetes prevention. Cell Metabolism. 2025. 37(12), 2323–2341.e6. (IF = 30.9, JCR ranking Q1, 3/191, Endocrinology & Metabolism, Co-first author).

  2. Dewei Ye, Jiating Huang, Jiaming Wu, Kang Xie, Xiang Gao, Kaixuan Yan, Pengfei Zhang, Ying Tao, Yun Li, Shufei Zang, Xianglu Rong, Jun Li, Jiao Guo. Integrative metagenomic and metabolomic analyses reveal gut microbiota-derived multiple hits connected to development of gestational diabetes mellitus in humans. Gut Microbes. 2023 Jan-Dec;15(1):2154552. (IF = 11.0, JCR ranking Q1, 7/119, Microbiology)

  3. Qin Li*, Cuishan Chen*, Jiaming Wu*, Liona C Poon, Chi Chiu Wang, Tin Chiu Li, Tao Zhang, Xianghao Guo, Liang Song, Xia Wang, Qian Zhang, Ziying Ye, Yongkang Yang, Jing Lu, Jianyu Yao, Dewei Ye, Yao Wang. Decreased serum soluble programmed cell death ligand-1 level as a potential biomarker for missed miscarriage. Human Reproduction. 2023 Nov 2;38(11):2128-2136. (IF = 6.1, JCR ranking Q1, 7/141, Obstetrics & Gynecology, Co-first author)

  4. Yongkang Yang*, Jiaming Wu*, Xia Wang, Jianyu Yao, Kim Shijian Lao, Yumei Qiao, Ying Xu, Yue Hu, Yanhong Feng, Yanchao Cui, Shuai Shi, Jing Zhang, Man Liang, Yong Pan, Kang Xie, Kaixuan Yan, Qin Li, Dewei Ye, Yao Wang. Circulating fibroblast growth factor 21 as a potential biomarker for missed abortion in humans. Fertil Steril. 2021 Oct;116(4):1040-1049. (IF = 7.0, JCR ranking Q1, 5/141, Obstetrics & Gynecology, Co-first author)

  5. Wu Jiaming, Gao Xiang, Xie Kang, Rong Xianglu, Ye Dewei, and Guo Jiao*. Key Technology and Challenges in The Transplantation of Human Fecal Microflora into Animal Models for the Investigation of Therapeutic Effect of Chinese Medicine on Glucolipid Metabolic Disorders. World Chinese Medicine. 2019, 14(1): 33 – 37. (In Chinese)

Patents

  1. Aimin Xu, Jiaming Wu. Anti-GDF15 and anti-GFRAL antibodies, GDF15 and GFRAL agonists, and related compositions, and methods of Use (US patent application No. 64/122,300 in 07/30/2026)

  2. WANG Yao, LI Qin, YANG Yongkang, WU Jiaming, POON Chiu Yee Liona, WANG Chi Chiu, LI Tin Chiu, Methods for diagnosing and predicting miscarriage in humans by quantifying serum levels of soluble programmed cell death ligand-1, US patents Serial No. 63/518.903.2023

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