生物醫藥技術全國重點實驗室
（香港大學）
State Key Laboratory of Pharmaceutical Biotechnology
（The University of Hong Kong)
Field of Research
Adipokine biology, postmenopausal osteoporosis, obesity and aging-related benign prostatic hyperplasia
Biography
Dr. JIANG Mengxue obtained her bachelor’s degree from Anhui medical university and master’s degree from Xiamen University. She is currently a postdoctoral fellow in the Department of Pharmacology and Pharmacy, HKU. Her research focuses on basic and translational studies of adipose tissue and adipokine biology in the development of postmenopausal osteoporosis and obesity-related benign prostatic hyperplasia.
Publications
1. Yuan L, Wu X, Zong J, Jiang M, Gao S, Zhang Z, Huang X, Zhu M, Xiang M, Wang L, Ping Z, Pan Y, Ye D, Xu A, Hoo RLC. Neutrophil serine proteases inhibit thermogenic capacity of visceral white adipose tissue. Nat Metab. 2026 Sep;8(9):1971-1989. doi: 10.1038/s42255-026-01598-6. Epub 2026 Aug 31. PMID: 42675151.
2. Zong J, Wu X, Huang X, Yuan L, Yuan K, Zhang Z, Jiang M, Ping Z, Cheong LY, Xu A, Hoo RLC. Adipocyte-derived shed Syndecan-4 suppresses lipolysis contributing to impaired adipose tissue browning and adaptive thermogenesis. Mol Metab. 2025 Jun; 96:102133. doi: 10.1016/j.molmet.2025.102133. Epub 2025 Apr 1. PMID: 40180176; PMCID: PMC12004711.
3. Wu X, Zhang Z, Li J, Zong J, Yuan L, Shu L, Cheong LY, Huang X, Jiang M, Ping Z, Xu A, Hoo RLC. Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis. Adv Sci (Weinh). 2025 Apr;12(15): e2408763. doi: 10.1002/advs.202408763. Epub 2025 Feb 22. PMID: 39985288; PMCID: PMC12005791.
4. Kuang Z#, Guo K#, Jiang M#, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T, Liu W, Fang M. The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer. 2023 Dec;129(12):1915-1929.
5. Liao B, Yang S, Geng L, Zong J, Zhang Z, Jiang M, Jiang X, Li S, Xu A, Chang J, Hoo RLC. Development of a therapeutic monoclonal antibody against circulating adipocyte fatty acid binding protein to treat ischaemic stroke. Br J Pharmacol. 2023 Nov 10.
6. Jiang M, Kuang Z, He Y, Cao Y, Yu T, Cheng J, Liu W, Wang W. SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth. Front Endocrinol (Lausanne). 2021 Jun 14; 12:624309.